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Microbial Bioinformatics

Length
3 days
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Course delivery
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Length
3 days
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Course delivery
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Course description

The aims of this course are to investigate how procaryotic and eucaryotic genomes are sequenced, constructed and annotated; and how the genomes from different classes of organism are compared; and to demonstrate the potential commercial exploitation of such genomic analysis.

Course content

•Aspects of the genomics of bacteria, viruses, yeast and fungi.

•Sequencing genomes: contig construction, genome completion, genome annotation.

•Comparative microbial genomics– microbial circular and line argenomes, mega- plasmids, reduced genomes– using a range of case studies.

•Diversity and phylogenetic relationships: 16S rDNA sequencing and other conserved sequences; cluster analysis; phylogenetic tree construction.

•Community DNA analysis, metagenomics, identification of uncultured organisms.

•Location of core genes for metabolism; virulence.

•Analysis of metabolic pathways, structure and function using KEGG.

Assessment will comprise an investigation of sequence data using bioinformatics databases, and a critique of the findings (100%).

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  • United Kingdom

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